UNC 0646( —— )

Catalog No. M22061 CAS No. 1320288-17-2

COA

Datasheet

HNMR

HPLC

MSDS

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Product Name

UNC 0646
Note

Research use only, not for human use.
Brief Description

UNC 0646 is a potent and selective inhibitor of the homologous protein lysine methyltransferases, G9a and GLP (IC50s: 6 nM/15 nM for G9a/GLP).
Description

UNC 0646 is a potent and selective inhibitor of the homologous protein lysine methyltransferases, G9a and GLP (IC50s: 6 nM/15 nM for G9a/GLP). UNC0646 potently blocks G9a/GLP methyltransferase activity in cells (IC50: 10 nM in MCF7 cells); exhibits low cellular toxicity (EC50: 4.7 μM in MCF7 cells).
In Vitro

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In Vivo

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Synonyms

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Pathway

Others
Target

Other Targets
Recptor

G9a| GLP
Research Area

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Indication

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CAS Number

1320288-17-2
Formula Weight

621.9
Molecular Formula

C36H59N7O2
Purity

>98% (HPLC)
Solubility

DMSO:30 mg/mL (48.24 mM; Need ultrasonic)
SMILES

COC1=C(OCCCN2CCCCC2)C=C2N=C(N=C(NC3CCN(CC3)C3CCCCC3)C2=C1)N1CCCN(CC1)C(C)C
Chemical Name

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1.Liu F, et al. Optimization of cellular activity of G9a inhibitors 7-aminoalkoxy-quinazolines. J Med Chem. 2011 Sep 8;54(17):6139-50.

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